Ayesha Harrison-Jex passed at the age of 40. She was diagnosed with cancer three years ago.
Shaq did not appear on Thursday’s broadcast on TNT but his posting partners Ernie Johnson, Charles Barkley and Kenny Smith were and they offered their condolences.
Shaq’s sister graduated from Florida A&M University with a bachelor’s and masters’ degree.
She will reportedly be laid to rest in a military ceremony and is expected to be buried next to O’Neal’s stepfather, Sgt. Phillip Harrison.